Dab tsi yog kev sib raug zoo ntawm kev nyuaj siab hauv nruab nrab hnub nyoog thiab Tau deposition?

Raws li kev tshawb fawb tshiab los ntawm cov kws tshawb fawb ntawm UT Health San Antonio thiab nws cov koom haum koom tes, cov neeg muaj hnub nyoog nruab nrab uas muaj cov tsos mob kev nyuaj siab muaj cov protein hu ua APOE.Kev hloov pauv hauv epsilon 4 Tej zaum yuav muaj peev xwm tsim tau ntau dua hauv thaj chaw ntawm lub hlwb uas tswj kev xav thiab nco.

news-3

Cov Kev Tshawb Fawb tau luam tawm nyob rau lub Rau Hli 2021 luam tawm ntawm Phau Ntawv Xov Xwm ntawm Alzheimer's Disease.Txoj Kev Tshawb Fawb tau ua raws li kev soj ntsuam kev nyuaj siab thiab kev kuaj pom ntawm positron emission tomography (PET) ntawm 201 tus neeg koom nrog ntau tiam neeg Framingham Heart Study.Qhov nruab nrab hnub nyoog ntawm cov neeg koom yog 53.

Qhov yuav pom tus kab mob no ntau xyoo ua ntej kuaj mob

PET feem ntau ua rau cov neeg laus, yog li Framingham STUDY ntawm PET hauv nruab nrab hnub nyoog yog qhov tshwj xeeb, hais tias Mitzi M. Gonzales, tus thawj coj ntawm kev tshawb fawb thiab kws kho mob hlwb ntawm Glenn Biggs Institute for Alzheimer's disease thiab Neurodegenerative Diseases, uas yog ib feem ntawm cov University of Texas Health Center ntawm SAN Antonio.

"Qhov no muab sijhawm txaus rau peb los kawm txog cov neeg muaj hnub nyoog nruab nrab thiab nkag siab txog yam uas yuav cuam tshuam nrog kev sib sau ntawm cov protein hauv cov tib neeg uas muaj kev txawj ntse," Dr. Gonzales tau hais."Yog tias cov neeg no mus rau kev tsim kho dementia, qhov kev tshawb fawb no yuav nthuav tawm cov muaj peev xwm ntau xyoo ua ntej kuaj mob."

Nws tsis muaj dab tsi ua nrog beta-amyloid

Beta-amyloid (Aβ) thiab Tau yog cov proteins uas nyob rau hauv lub hlwb ntawm cov neeg uas muaj Alzheimer's kab mob thiab feem ntau nce maj mam nrog lub hnub nyoog thiab.Txoj kev tshawb nrhiav pom tsis muaj kev sib raug zoo ntawm cov tsos mob kev nyuaj siab thiab kev nyuaj siab thiab beta-amyloid.Nws tsuas yog txuam nrog Tau, thiab tsuas yog nrog cov neeg nqa khoom ntawm APOE ε4 kev hloov pauv.Kwv yees li ib feem peb ntawm 201 tus neeg mob (47) nqa ε4 noob vim tias lawv muaj tsawg kawg yog ib qho ε4 allele.

Nqa ib daim qauv ntawm APOEε4 gene ua rau muaj kev pheej hmoo ntawm tus kab mob alzheimer los ntawm ob mus rau peb zaug, tab sis qee cov neeg uas muaj cov noob hloov pauv tuaj yeem nyob rau hauv lawv cov 80s lossis 90s yam tsis tau tsim tus kab mob."Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias tsuas yog vim hais tias ib tug neeg raug txheeb xyuas tias nqa APOE ε4 tsis tau txhais hais tias nws yuav tsim dementia yav tom ntej," Dr. Gonzales tau hais.Nws tsuas yog txhais tau tias cov ceg txheem ntseeg siab dua. "

Cov tsos mob ntawm kev nyuaj siab (kev nyuaj siab yog tias cov tsos mob hnyav txaus kom ua tau raws li qhov kev kuaj mob no) tau soj ntsuam thaum lub sij hawm ntawm PET imaging thiab yim xyoo ua ntej siv Epidemiological Research Center Depression Scale.Cov tsos mob ntawm kev nyuaj siab thiab kev sib raug zoo ntawm kev nyuaj siab thiab PET tshwm sim ntawm ob lub sij hawm cov ntsiab lus raug soj ntsuam, kho rau hnub nyoog thiab poj niam txiv neej.

Emotional thiab cognitive chaw

Txoj kev tshawb no qhia txog kev sib koom ua ke ntawm cov tsos mob ntawm kev nyuaj siab thiab kev nce hauv tau hauv ob thaj tsam ntawm lub hlwb, lub hauv siab cortex thiab amygdala.Dr. Gonzales tau hais tias "Cov koom haum no tsis txhais hais tias tau tsub zuj zuj ua rau muaj kev nyuaj siab los yog ua rau lwm tus," Dr. Gonzales tau hais."Peb tsuas pom ob yam khoom no hauv ε4 cov neeg nqa khoom."

Nws tau sau tseg tias lub cortex entorhinal yog ib qho tseem ceeb rau kev sib koom ua ke ntawm kev nco thiab zoo li yog thaj chaw uas muaj protein ntau tshwm sim thaum ntxov.Lub caij no, amygdala xav tias yog qhov chaw siab ntsws ntawm lub hlwb.

"Kev tshawb fawb ntev yog xav tau kom nkag siab ntxiv txog dab tsi tshwm sim, tab sis nws yog qhov nthuav kom xav txog qhov cuam tshuam rau kev kho mob ntawm peb qhov kev tshawb pom ntawm kev paub txog kev xav thiab kev xav," Dr. Gonzales tau hais.


Post lub sij hawm: 26-08-21